WHAT IS IPILIMUMAB (YERVOY)?
Ipilimumab is a cancer medicine that is used alone or in combination with other medicines to treat certain types of cancer such as:
skin cancer (melanoma);
non-small cell lung cancer (NSCLC);
pleural mesothelioma (cancer that affects the lining of the lungs and chest wall);
liver cancer; or
colorectal cancer that has certain specific DNA mutations.
Ipilimumab is often given when the cancer has spread to other parts of the body, or cannot be surgically removed, or has come back after prior treatment.
Ipilimumab is given for NSCLC only if your tumor tests positive for “PD-L1” and does not have an abnormal “EGFR” or “ALK” (a specific genetic marker).
Ipilimumab may also be used for purposes not listed in this medication guide.
WHAT ARE THE POSSIBLE SIDE EFFECTS OF IPILIMUMAB (YERVOY)?
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Some side effects may occur during the injection. Tell your caregiver if you feel dizzy, light-headed, short of breath, itchy, tingly, chilled, or feverish.
Serious and sometimes fatal reactions may occur during treatment with ipilimumab or months after stopping. Call your doctor right away if you have symptoms such as:
severe or ongoing diarrhea, severe stomach pain, bloody or tarry stools;
fever, swollen glands, body aches;
new or worsening skin rash, itching, or blistering;
chest pain, irregular heartbeats;
severe muscle weakness, ongoing pain in your muscles or joints;
numbness or tingling in your hands or feet;
vision problems, eye pain or redness;
lung problems–new or worsening cough, chest pain, feeling short of breath;
kidney problems–little or no urination, swelling in your feet or ankles, blood in your urine;
liver problems–right-sided upper stomach pain, tiredness, bruising or bleeding, dark urine, yellowing of your skin or eyes;
signs of a hormonal disorder–frequent or unusual headaches, lack of energy, dizziness, fainting, mood or behavior changes, increased thirst or urination, feeling cold, weight gain, or weight loss; or
symptoms of brain swelling–confusion, headache, memory problems, hallucinations, neck stiffness, drowsiness, seizure (convulsions).